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README.md

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# AlignMe
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Alignment of membrane proteins
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Pairwise alignment of membrane protein sequences
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## Required external libraries:
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- boost library headers (boost.org), namely shared_ptr.hpp
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## Required external libraries
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Boost library headers (boost.org), namely shared_ptr.hpp
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## Optional external code
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[BLAST](https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE_TYPE=BlastDocs&DOC_TYPE=Download) - for generating position specific substitution matrices
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[OCTOPUS](http://octopus.cbr.su.se/index.php?about=download) - for generating transmembrane predictions
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## How to install:
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## How to install
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- change directory to the appropriate folder in your terminal
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- type "make"
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- the executable is created in this folder and ready to use
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## How to use:
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## How to use
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- have a look at the manual AlignMe_manual.pdf and try out some examples
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- scripts/use_best_parameters.pl can be used for running AlignMePST jobs if PSSM, secondary structure predictions, and transmembrane predictions are available.
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## Online server:
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- our online server is available at [http://www.bioinfo.mpg.de/AlignMe/](http://www.bioinfo.mpg.de/AlignMe/)
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## Online server
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Our online server is available at [http://www.bioinfo.mpg.de/AlignMe/](http://www.bioinfo.mpg.de/AlignMe/)
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If you have questions about the usage of this program or discovered a
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bug, then please post a message on github or write to: AlignMe@rzg.mpg.de

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