diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
new file mode 100644
index 00000000..4a646e20
--- /dev/null
+++ b/.github/workflows/wheels.yml
@@ -0,0 +1,140 @@
+name: Wheels
+
+on:
+  push:
+    branches:
+      - master
+    paths:
+      - ".github/workflows/wheels.yml"
+      - "python/**"
+      - "source/**"
+  pull_request:
+    branches:
+      - master
+    paths:
+      - ".github/workflows/wheels.yml"
+      - "python/**"
+      - "source/**"
+  release:
+    types: [published]
+  workflow_dispatch:
+
+concurrency:
+  group: wheels-${{ github.workflow }}-${{ github.ref }}
+  cancel-in-progress: true
+
+jobs:
+  build-wheels:
+    runs-on: ${{ matrix.os }}
+    strategy:
+      matrix:
+        os:
+          - ubuntu-latest
+        archs:
+          - "x86_64"
+          - "i686"
+        impl:
+          - "manylinux"
+          - "musllinux"
+        include:
+          - os: windows-latest
+            archs: "AMD64"
+            impl: win
+          - os: windows-latest
+            archs: "x86"
+            impl: win
+          - os: macos-13
+            archs: "universal2"
+            impl: macosx
+      fail-fast: false
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+        with:
+          fetch-depth: 0
+
+      - name: Setup QEMU for Linux cross-compilation
+        if: runner.os == 'Linux'
+        uses: docker/setup-qemu-action@v3
+        with:
+          platforms: all
+
+      - name: Clone LLVM project
+        shell: bash
+        run: |
+          git clone -b release/6.x https://github.com/llvm/llvm-project.git
+        working-directory: python
+
+      - name: Setup LLVM project
+        shell: bash
+        run: |
+          echo 'add_subdirectory(binder)' > python/llvm-project/clang-tools-extra/CMakeLists.txt
+          cp -r source python/llvm-project/clang-tools-extra/binder
+
+      - name: Build wheels
+        uses: pypa/cibuildwheel@v2.23.3
+        env:
+          CIBW_BUILD: cp313-${{ matrix.impl }}*
+          CIBW_ARCHS: ${{ matrix.archs }}
+        with:
+          package-dir: python
+
+      - name: Upload wheels to artifacts
+        uses: actions/upload-artifact@v4
+        with:
+          name: cppbinder-wheels-${{ matrix.os }}-${{ matrix.archs }}-${{ matrix.impl }}-${{ github.event_name == 'release' && github.ref_name || github.sha }}
+          path: ./wheelhouse/*.whl
+
+  build-sdist:
+    runs-on: ubuntu-22.04
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+        with:
+          fetch-depth: 0
+
+      - name: Clone LLVM project
+        shell: bash
+        run: |
+          git clone -b release/6.x https://github.com/llvm/llvm-project.git
+        working-directory: python
+
+      - name: Setup LLVM project
+        shell: bash
+        run: |
+          echo 'add_subdirectory(binder)' > python/llvm-project/clang-tools-extra/CMakeLists.txt
+          cp -r source python/llvm-project/clang-tools-extra/binder
+
+      - name: Setup build and build source distribution
+        run: |
+          pipx install build
+          pipx run build --sdist --outdir dist
+        working-directory: python
+
+      - name: Upload source distribution to artifacts
+        uses: actions/upload-artifact@v4
+        with:
+          name: cppbinder-sdist-${{ github.event_name == 'release' && github.ref_name || github.sha }}
+          path: ./python/dist/*.tar.gz
+
+  publish:
+    needs: [build-wheels, build-sdist]
+    if: github.event_name == 'release'
+    runs-on: ubuntu-22.04
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+
+      - name: Download wheels and source distribution
+        uses: actions/download-artifact@v4
+        with:
+          pattern: cppbinder-*
+          path: dist
+          merge-multiple: true
+
+      - name: Publish package to PyPI
+        uses: pypa/gh-action-pypi-publish@v1.8.14
+        with:
+          user: __token__
+          password: ${{ secrets.PYPI_API_TOKEN }}
+          packages-dir: dist
diff --git a/documentation/install.rst b/documentation/install.rst
index e30168dd..465dc894 100644
--- a/documentation/install.rst
+++ b/documentation/install.rst
@@ -1,5 +1,18 @@
-Installation
-============
+Install from PyPI
+=================
+
+The easiest way to install Binder is to use pip to install pre-built wheels from PyPI:
+
+.. code-block:: bash
+
+    pip install cppbinder
+
+This will install the latest version of Binder and its dependencies.
+
+To build Binder from source, follow the instructions below.
+
+Build and install from source
+=============================
 **Binder** is written in C++11 and must be built before use. This page describes the steps for the build process.
 Please note that installation require up to ~2.6+ Gb of free disk space.
 
diff --git a/python/.gitignore b/python/.gitignore
new file mode 100644
index 00000000..9a0dfc3d
--- /dev/null
+++ b/python/.gitignore
@@ -0,0 +1,143 @@
+# Byte-compiled / optimized / DLL files
+__pycache__/
+*.py[cod]
+*$py.class
+
+# C extensions
+*.so
+
+# Distribution / packaging
+.Python
+build/
+develop-eggs/
+dist/
+downloads/
+eggs/
+.eggs/
+lib/
+lib64/
+parts/
+sdist/
+var/
+wheels/
+pip-wheel-metadata/
+share/python-wheels/
+*.egg-info/
+.installed.cfg
+*.egg
+MANIFEST
+
+# PyInstaller
+#  Usually these files are written by a python script from a template
+#  before PyInstaller builds the exe, so as to inject date/other infos into it.
+*.manifest
+*.spec
+
+# Installer logs
+pip-log.txt
+pip-delete-this-directory.txt
+
+# Unit test / coverage reports
+htmlcov/
+.tox/
+.nox/
+.coverage
+.coverage.*
+.cache
+nosetests.xml
+coverage.xml
+*.xml
+*.cover
+*.py,cover
+.hypothesis/
+.pytest_cache/
+
+# Translations
+*.mo
+*.pot
+
+# Django stuff:
+*.log
+local_settings.py
+db.sqlite3
+db.sqlite3-journal
+
+# Flask stuff:
+instance/
+.webassets-cache
+
+# Scrapy stuff:
+.scrapy
+
+# Sphinx documentation
+docs/_build/
+
+# PyBuilder
+target/
+
+# Jupyter Notebook
+.ipynb_checkpoints
+
+# IPython
+profile_default/
+ipython_config.py
+
+# pyenv
+.python-version
+
+# pipenv
+#   According to pypa/pipenv#598, it is recommended to include Pipfile.lock in version control.
+#   However, in case of collaboration, if having platform-specific dependencies or dependencies
+#   having no cross-platform support, pipenv may install dependencies that don't work, or not
+#   install all needed dependencies.
+#Pipfile.lock
+
+# PEP 582; used by e.g. github.com/David-OConnor/pyflow
+__pypackages__/
+
+# Celery stuff
+celerybeat-schedule
+celerybeat.pid
+
+# SageMath parsed files
+*.sage.py
+
+# Environments
+.env
+.venv
+env/
+venv/
+ENV/
+env.bak/
+venv.bak/
+
+# Spyder project settings
+.spyderproject
+.spyproject
+
+# Rope project settings
+.ropeproject
+
+# mkdocs documentation
+/site
+
+# mypy
+.mypy_cache/
+.dmypy.json
+dmypy.json
+
+# Pyre type checker
+.pyre/
+
+# IDE config files
+.vs/
+.vscode/
+.VSCodeCounter/
+.idea/
+
+# CMake build/debug directory
+cmake-build-*/
+
+# Binder build files
+binder/_version.py
+binder/bin
diff --git a/python/CMakeLists.txt b/python/CMakeLists.txt
new file mode 100644
index 00000000..2d3d1f1b
--- /dev/null
+++ b/python/CMakeLists.txt
@@ -0,0 +1,4 @@
+cmake_minimum_required(VERSION 3.15)
+project(binder LANGUAGES CXX C)
+
+add_subdirectory(llvm-project/llvm)
diff --git a/python/LICENSE b/python/LICENSE
new file mode 120000
index 00000000..ea5b6064
--- /dev/null
+++ b/python/LICENSE
@@ -0,0 +1 @@
+../LICENSE
\ No newline at end of file
diff --git a/python/README.md b/python/README.md
new file mode 120000
index 00000000..32d46ee8
--- /dev/null
+++ b/python/README.md
@@ -0,0 +1 @@
+../README.md
\ No newline at end of file
diff --git a/python/binder/__init__.py b/python/binder/__init__.py
new file mode 100644
index 00000000..845e0c64
--- /dev/null
+++ b/python/binder/__init__.py
@@ -0,0 +1,8 @@
+import os
+import subprocess
+import sys
+
+
+def binder():
+    BINDER_BIN_DIR = os.path.join(os.path.dirname(__file__), "bin")
+    raise SystemExit(subprocess.call([os.path.join(BINDER_BIN_DIR, "binder"), *sys.argv[1:]], close_fds=False))
diff --git a/python/binder/__main__.py b/python/binder/__main__.py
new file mode 100644
index 00000000..03d32031
--- /dev/null
+++ b/python/binder/__main__.py
@@ -0,0 +1,4 @@
+from binder import binder
+
+if __name__ == "__main__":
+    binder()
diff --git a/python/pyproject.toml b/python/pyproject.toml
new file mode 100644
index 00000000..0892bb46
--- /dev/null
+++ b/python/pyproject.toml
@@ -0,0 +1,76 @@
+[build-system]
+requires = ["scikit-build-core>=0.10.0", "setuptools", "setuptools-scm"]
+build-backend = "scikit_build_core.build"
+
+[project]
+name = "cppbinder"
+description = "Binder, tool for automatic generation of Python bindings"
+readme = "README.md"
+dynamic = ["version"]
+authors = [
+    {name = "Rosetta Commons"},
+]
+classifiers = [
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 2",
+    "Programming Language :: Python :: 3",
+    "License :: OSI Approved :: MIT License",
+    "Operating System :: OS Independent",
+]
+requires-python = ">=2.7"
+
+[project.urls]
+Homepage = "https://github.com/RosettaCommons/binder/"
+Documentation = "https://cppbinder.readthedocs.io/"
+"Bug Tracker" = "https://github.com/RosettaCommons/binder/issues/"
+
+[project.scripts]
+binder = "binder:binder"
+
+[tool.scikit-build]
+minimum-version = "build-system.requires"
+build-dir = "build/{wheel_tag}"
+
+# Print verbose output
+build.verbose = true
+logging.level = "INFO"
+
+# Dynamic versioning
+metadata.version.provider = "scikit_build_core.metadata.setuptools_scm"
+
+# Components to install and targets to build
+install.components = ["binder"]
+build.targets = ["binder"]
+
+# Cmake version
+cmake.version = ">=3.15,<4"
+
+# Cmake defines
+cmake.define.LLVM_ENABLE_EH = "ON"
+cmake.define.LLVM_ENABLE_RTTI = "ON"
+cmake.define.LLVM_ENABLE_PROJECTS = "clang"
+cmake.define.CMAKE_POLICY_VERSION_MINIMUM = "3.15"
+
+# Wheel configuration
+wheel.packages = ["binder"]
+wheel.install-dir = "binder"
+wheel.py-api = "py2.py3"
+wheel.expand-macos-universal-tags = true
+
+[tool.cibuildwheel]
+build = "cp313-*"
+build-verbosity = 1
+test-requires = ["pytest"]
+test-command = "pytest {package}/tests"
+musllinux-x86_64-image = "quay.io/pypa/musllinux_1_1_x86_64:latest"
+musllinux-i686-image = "quay.io/pypa/musllinux_1_1_i686:latest"
+musllinux-aarch64-image = "quay.io/pypa/musllinux_1_1_aarch64:latest"
+musllinux-ppc64le-image = "quay.io/pypa/musllinux_1_1_ppc64le:latest"
+musllinux-s390x-image = "quay.io/pypa/musllinux_1_1_s390x:latest"
+
+[tool.cibuildwheel.macos]
+archs = ["universal2"]
+
+[tool.setuptools_scm]
+root = ".."
+git_describe_command = ["git", "describe", "--long", "--tags", "--match", "*[0-9]*"]
diff --git a/python/tests/test_binder.py b/python/tests/test_binder.py
new file mode 100644
index 00000000..cc97dc76
--- /dev/null
+++ b/python/tests/test_binder.py
@@ -0,0 +1,12 @@
+import re
+import subprocess
+
+
+def test_check_binder_llvm_version():
+    # Check the output of the `binder -version` command to obtain the versions of Binder and LLVM
+    output = subprocess.check_output(["binder", "-version"]).decode()
+    pattern = r"binder ([\d\.]+)\nLLVM ([\d\.]+)"
+    binder_version, llvm_version = re.match(pattern, output).groups()
+
+    # Check the versions of LLVM
+    assert llvm_version == "6.0.1", f"LLVM version mismatch: {llvm_version} != 6.0.1"
diff --git a/source/CMakeLists.txt b/source/CMakeLists.txt
index 06a0353a..5523d3b1 100644
--- a/source/CMakeLists.txt
+++ b/source/CMakeLists.txt
@@ -123,6 +123,6 @@ else()
     clangFrontend
     )
 endif()
-install(FILES ${CMAKE_CURRENT_BINARY_DIR}/binder
+install(TARGETS binder
 PERMISSIONS WORLD_EXECUTE WORLD_READ OWNER_WRITE OWNER_READ OWNER_EXECUTE
-DESTINATION ${CMAKE_INSTALL_BINDIR})
+DESTINATION ${CMAKE_INSTALL_BINDIR} COMPONENT binder)