diff --git a/tools/dockerfile/distribtest/python_alpine_aarch64.current_version b/tools/dockerfile/distribtest/python_alpine_aarch64.current_version
index a3efd8f5bcc0b..5b3080154e40a 100644
--- a/tools/dockerfile/distribtest/python_alpine_aarch64.current_version
+++ b/tools/dockerfile/distribtest/python_alpine_aarch64.current_version
@@ -1 +1 @@
-us-docker.pkg.dev/grpc-testing/testing-images-public/python_alpine_aarch64:086c6b7ba4177b5c086a4e1e36019fdd1d86a061@sha256:da5d191e62811fd3470d593aa9a7c2bfc8ee7d3453db92db13d62edb2eb9f39e
\ No newline at end of file
+us-docker.pkg.dev/grpc-testing/testing-images-public/python_alpine_aarch64:78b5c9d459ceaedfa8dc8fa6dc52ce11666dd581@sha256:bcdfc865daa8c61dc6f9b67ddab63d47fcacb109ed57de5b9a7673dff907e02c
\ No newline at end of file
diff --git a/tools/dockerfile/distribtest/python_alpine_aarch64/Dockerfile b/tools/dockerfile/distribtest/python_alpine_aarch64/Dockerfile
index a7500e39aa557..27d25043fc704 100644
--- a/tools/dockerfile/distribtest/python_alpine_aarch64/Dockerfile
+++ b/tools/dockerfile/distribtest/python_alpine_aarch64/Dockerfile
@@ -12,7 +12,8 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-FROM python:3.10-alpine3.14
+# this an aarch64 image
+FROM arm64v8/python:3.10-alpine
 
 # Our test infrastructure demands bash
 RUN apk update && apk add bash
diff --git a/tools/internal_ci/linux/arm64/grpc_distribtests_python_arm64.cfg b/tools/internal_ci/linux/arm64/grpc_distribtests_python_arm64.cfg
index ffc02e606df42..f166d92fd5f16 100644
--- a/tools/internal_ci/linux/arm64/grpc_distribtests_python_arm64.cfg
+++ b/tools/internal_ci/linux/arm64/grpc_distribtests_python_arm64.cfg
@@ -15,7 +15,7 @@
 # Config file for the internal CI (in protobuf text format)
 
 # Location of the continuous shell script in repository.
-build_file: "grpc/tools/internal_ci/linux/grpc_distribtests_python_arm64.sh"
+build_file: "grpc/tools/internal_ci/linux/grpc_distribtests_python.sh"
 timeout_mins: 240
 action {
   define_artifacts {
@@ -24,3 +24,8 @@ action {
     regex: "github/grpc/artifacts/**"
   }
 }
+
+env_vars {
+  key: "TASK_RUNNER_EXTRA_FILTERS"
+  value: "aarch64 musllinux_1_1"
+}
diff --git a/tools/internal_ci/linux/grpc_distribtests_python.cfg b/tools/internal_ci/linux/grpc_distribtests_python.cfg
index ee17d7a29202f..f7a6ea46a1f77 100644
--- a/tools/internal_ci/linux/grpc_distribtests_python.cfg
+++ b/tools/internal_ci/linux/grpc_distribtests_python.cfg
@@ -24,3 +24,8 @@ action {
     regex: "github/grpc/artifacts/**"
   }
 }
+
+env_vars {
+  key: "TASK_RUNNER_EXTRA_FILTERS"
+  value: "-e aarch64 musllinux_1_1"
+}
diff --git a/tools/internal_ci/linux/grpc_distribtests_python.sh b/tools/internal_ci/linux/grpc_distribtests_python.sh
index dd5dba63dcf95..ce3541485d3ae 100755
--- a/tools/internal_ci/linux/grpc_distribtests_python.sh
+++ b/tools/internal_ci/linux/grpc_distribtests_python.sh
@@ -23,10 +23,19 @@ cd $(dirname $0)/../../..
 
 source tools/internal_ci/helper_scripts/prepare_build_linux_rc
 
-# some distribtests use a pre-registered binfmt_misc hook
-# to automatically execute foreign binaries (such as aarch64)
-# under qemu emulator.
-source tools/internal_ci/helper_scripts/prepare_qemu_rc
+IS_AARCH64_MUSL=""
+if [[ "${TASK_RUNNER_EXTRA_FILTERS}" == "aarch64 musllinux_1_1" || "${TASK_RUNNER_EXTRA_FILTERS}" == "presubmit aarch64 musllinux_1_1" ]]; then
+  IS_AARCH64_MUSL="True"
+fi
+
+if [[ "${IS_AARCH64_MUSL}" == "True" ]]; then
+  echo "Skipping prepare_qemu_rc'"
+else
+  # some distribtests use a pre-registered binfmt_misc hook
+  # to automatically execute foreign binaries (such as aarch64)
+  # under qemu emulator.
+  source tools/internal_ci/helper_scripts/prepare_qemu_rc
+fi
 
 # configure ccache
 source tools/internal_ci/helper_scripts/prepare_ccache_rc
@@ -40,7 +49,12 @@ mkdir -p input_artifacts
 cp -r artifacts/* input_artifacts/ || true
 
 # This step simply collects python artifacts from subdirectories of input_artifacts/ and copies them to artifacts/
-tools/run_tests/task_runner.py -f package linux python -x build_packages/sponge_log.xml || FAILED="true"
+if [[ "${IS_AARCH64_MUSL}" == "True" ]]; then
+  # Not using TASK_RUNNER_EXTRA_FILTERS since we don't have a target with presubmit tag.
+  tools/run_tests/task_runner.py -f package linux python musllinux_1_1 aarch64 -x build_packages/sponge_log.xml || FAILED="true"
+else
+  tools/run_tests/task_runner.py -f package linux python -x build_packages/sponge_log.xml || FAILED="true"
+fi
 
 # the next step expects to find the artifacts from the previous step in the "input_artifacts" folder.
 # in addition to that, preserve the contents of "artifacts" directory since we want kokoro
@@ -52,7 +66,12 @@ cp -r artifacts/* input_artifacts/ || true
 # Run all python linux distribtests
 # We run the distribtests even if some of the artifacts have failed to build, since that gives
 # a better signal about which distribtest are affected by the currently broken artifact builds.
-tools/run_tests/task_runner.py -f distribtest linux python ${TASK_RUNNER_EXTRA_FILTERS} -j 12 -x distribtests/sponge_log.xml || FAILED="true"
+if [[ "${IS_AARCH64_MUSL}" == "True" ]]; then
+  # We're using alpine as tag in distribtest targets.
+  tools/run_tests/task_runner.py -f distribtest linux python aarch64 alpine -j 12 -x distribtests/sponge_log.xml || FAILED="true"
+else
+  tools/run_tests/task_runner.py -f distribtest linux python ${TASK_RUNNER_EXTRA_FILTERS} -j 12 -x distribtests/sponge_log.xml || FAILED="true"
+fi
 
 # This step checks if any of the artifacts exceeds a per-file size limit.
 tools/internal_ci/helper_scripts/check_python_artifacts_size.sh
diff --git a/tools/internal_ci/linux/pull_request/grpc_distribtests_python.cfg b/tools/internal_ci/linux/pull_request/grpc_distribtests_python.cfg
index ccc02bff0226d..7696736086d43 100644
--- a/tools/internal_ci/linux/pull_request/grpc_distribtests_python.cfg
+++ b/tools/internal_ci/linux/pull_request/grpc_distribtests_python.cfg
@@ -27,5 +27,5 @@ action {
 
 env_vars {
   key: "TASK_RUNNER_EXTRA_FILTERS"
-  value: "presubmit"
+  value: "presubmit -e aarch64 musllinux_1_1"
 }
diff --git a/tools/internal_ci/linux/pull_request/grpc_distribtests_python_arm64.cfg b/tools/internal_ci/linux/pull_request/grpc_distribtests_python_arm64.cfg
index 80f51498c0795..0eb0a74388553 100644
--- a/tools/internal_ci/linux/pull_request/grpc_distribtests_python_arm64.cfg
+++ b/tools/internal_ci/linux/pull_request/grpc_distribtests_python_arm64.cfg
@@ -15,7 +15,7 @@
 # Config file for the internal CI (in protobuf text format)
 
 # Location of the continuous shell script in repository.
-build_file: "grpc/tools/internal_ci/linux/grpc_distribtests_python_arm64.sh"
+build_file: "grpc/tools/internal_ci/linux/grpc_distribtests_python.sh"
 timeout_mins: 240
 action {
   define_artifacts {
@@ -27,5 +27,5 @@ action {
 
 env_vars {
   key: "TASK_RUNNER_EXTRA_FILTERS"
-  value: "presubmit"
+  value: "presubmit aarch64 musllinux_1_1"
 }
diff --git a/tools/internal_ci/linux/pull_request/grpc_examples_tests_cpp.cfg b/tools/internal_ci/linux/pull_request/grpc_examples_tests_cpp.cfg
index 5eef82d3e3a5e..0237477b6322f 100644
--- a/tools/internal_ci/linux/pull_request/grpc_examples_tests_cpp.cfg
+++ b/tools/internal_ci/linux/pull_request/grpc_examples_tests_cpp.cfg
@@ -23,3 +23,13 @@ action {
     regex: "github/grpc/reports/**"
   }
 }
+
+env_vars {
+  key: "TASK_RUNNER_EXTRA_FILTERS"
+  value: "aarch64 -e x64 x86 armv7"
+}
+
+# env_vars {
+#   key: "TASK_RUNNER_EXCLUDE_FILTERS"
+#   value: "x64 x86 armv7"
+# }
diff --git a/tools/internal_ci/linux/release/grpc_distribtests_python.cfg b/tools/internal_ci/linux/release/grpc_distribtests_python.cfg
index 6ed2e7d67f603..bd44c7cc862e8 100644
--- a/tools/internal_ci/linux/release/grpc_distribtests_python.cfg
+++ b/tools/internal_ci/linux/release/grpc_distribtests_python.cfg
@@ -24,3 +24,8 @@ action {
     regex: "github/grpc/artifacts/**"
   }
 }
+
+env_vars {
+  key: "TASK_RUNNER_EXTRA_FILTERS"
+  value: "-e aarch64 musllinux_1_1"
+}
diff --git a/tools/run_tests/artifacts/package_targets.py b/tools/run_tests/artifacts/package_targets.py
index dabfb452880d9..8cffe7b98106b 100644
--- a/tools/run_tests/artifacts/package_targets.py
+++ b/tools/run_tests/artifacts/package_targets.py
@@ -142,9 +142,17 @@ def build_jobspec(self, inner_jobs=None):
 class PythonPackage:
     """Collects python eggs and wheels created in the artifact phase"""
 
-    def __init__(self):
+    def __init__(self, platform="", arch=""):
         self.name = "python_package"
         self.labels = ["package", "python", "linux"]
+        self.platform = platform
+        self.arch = arch
+        if self.platform:
+            self.labels.append(platform)
+            self.name += "_" + platform
+        if self.arch:
+            self.labels.append(arch)
+            self.name += "_" + arch
 
     def pre_build_jobspecs(self):
         return []
@@ -154,9 +162,16 @@ def build_jobspec(self, inner_jobs=None):
         # since the python package build does very little, we can use virtually
         # any image that has new-enough python, so reusing one of the images used
         # for artifact building seems natural.
+        dockerfile_dir = (
+            "tools/dockerfile/grpc_artifact_python_manylinux2014_x64"
+        )
+        if "musllinux_1_1" in self.platform and "aarch64" in self.arch:
+            dockerfile_dir = (
+                "tools/dockerfile/grpc_artifact_python_musllinux_1_1_aarch64"
+            )
         return create_docker_jobspec(
             self.name,
-            "tools/dockerfile/grpc_artifact_python_manylinux2014_x64",
+            dockerfile_dir,
             "tools/run_tests/artifacts/build_package_python.sh",
             environ={"PYTHON": "/opt/python/cp39-cp39/bin/python"},
         )
@@ -189,5 +204,6 @@ def targets():
         CSharpPackage("windows"),
         RubyPackage(),
         PythonPackage(),
+        PythonPackage("musllinux_1_1", "aarch64"),
         PHPPackage(),
     ]
diff --git a/tools/run_tests/task_runner.py b/tools/run_tests/task_runner.py
index fb2502d2a282e..1ecaaa63a69c8 100755
--- a/tools/run_tests/task_runner.py
+++ b/tools/run_tests/task_runner.py
@@ -71,6 +71,14 @@ def _create_build_map():
     default=[],
     help="Filter targets to build with AND semantics.",
 )
+argp.add_argument(
+    "-e",
+    "--exclude",
+    choices=sorted(_BUILD_MAP.keys()),
+    nargs="+",
+    default=[],
+    help="Target labels to exclude from building.",
+)
 argp.add_argument("-j", "--jobs", default=multiprocessing.cpu_count(), type=int)
 argp.add_argument(
     "-x",
@@ -106,6 +114,9 @@ def _create_build_map():
 # Among targets selected by -b, filter out those that don't match the filter
 targets = [t for t in targets if all(f in t.labels for f in args.filter)]
 
+# Exclude target if it has ALL of the specified exclude labels.
+targets = [t for t in targets if not all(l in args.exclude for l in t.labels)]
+
 print("Will build %d targets:" % len(targets))
 for target in targets:
     print("  %s, labels %s" % (target.name, target.labels))