diff --git a/.github/workflows/compilation_on_android_ubuntu.yml b/.github/workflows/compilation_on_android_ubuntu.yml
index 44c8d5168c..ab40d77899 100644
--- a/.github/workflows/compilation_on_android_ubuntu.yml
+++ b/.github/workflows/compilation_on_android_ubuntu.yml
@@ -618,49 +618,6 @@ jobs:
             llvm_cache_key: ${{ needs.build_llvm_libraries_on_ubuntu_2204.outputs.cache_key }}
             running_mode: aot
             test_option: $WAMR_COMPILER_TEST_OPTIONS
-        exclude:
-          # incompatible modes and features
-          # classic-interp doesn't support simd
-          - running_mode: "classic-interp"
-            test_option: $SIMD_TEST_OPTIONS
-          # llvm jit doesn't support multi module
-          - running_mode: "jit"
-            test_option: $MULTI_MODULES_TEST_OPTIONS
-          # fast-jit doesn't support multi module, simd
-          - running_mode: "fast-jit"
-            test_option: $MULTI_MODULES_TEST_OPTIONS
-          - running_mode: "fast-jit"
-            test_option: $SIMD_TEST_OPTIONS
-          # multi-tier-jit doesn't support multi module, simd
-          - running_mode: "multi-tier-jit"
-            test_option: $MULTI_MODULES_TEST_OPTIONS
-          - running_mode: "multi-tier-jit"
-            test_option: $SIMD_TEST_OPTIONS
-          # fast-jit and multi-tier-jit don't support GC
-          - running_mode: "fast-jit"
-            test_option: $GC_TEST_OPTIONS
-          - running_mode: "multi-tier-jit"
-            test_option: $GC_TEST_OPTIONS
-          # fast-interp, fast-jit, llvm-jit, multi-tier-jit don't support Memory64
-          - running_mode: "fast-interp"
-            test_option: $MEMORY64_TEST_OPTIONS
-          - running_mode: "fast-jit"
-            test_option: $MEMORY64_TEST_OPTIONS
-          - running_mode: "jit"
-            test_option: $MEMORY64_TEST_OPTIONS
-          - running_mode: "multi-tier-jit"
-            test_option: $MEMORY64_TEST_OPTIONS
-          # aot, fast-interp, fast-jit, llvm-jit, multi-tier-jit don't support Multi Memory
-          - running_mode: "aot"
-            test_option: $MULTI_MEMORY_TEST_OPTIONS
-          - running_mode: "fast-interp"
-            test_option: $MULTI_MEMORY_TEST_OPTIONS
-          - running_mode: "fast-jit"
-            test_option: $MULTI_MEMORY_TEST_OPTIONS
-          - running_mode: "jit"
-            test_option: $MULTI_MEMORY_TEST_OPTIONS
-          - running_mode: "multi-tier-jit"
-            test_option: $MULTI_MEMORY_TEST_OPTIONS
 
     steps:
       - name: checkout
diff --git a/.github/workflows/nightly_run.yml b/.github/workflows/nightly_run.yml
index d9841a2b39..da5003ac94 100644
--- a/.github/workflows/nightly_run.yml
+++ b/.github/workflows/nightly_run.yml
@@ -617,24 +617,11 @@ jobs:
             sanitizer: tsan
           - running_mode: "multi-tier-jit"
             sanitizer: tsan
-          # classic-interp and fast-interp don't support simd
-          - running_mode: "classic-interp"
-            test_option: $SIMD_TEST_OPTIONS
+          # simd128.h brings ubsan errors
+          # like: negation of XXXcannot be represented in type 'long int';
+          #       cast to an unsigned type to negate this value to itself
           - running_mode: "fast-interp"
-            test_option: $SIMD_TEST_OPTIONS
-          # llvm jit doesn't support multi module
-          - running_mode: "jit"
-            test_option: $MULTI_MODULES_TEST_OPTIONS
-          # fast-jit doesn't support multi module, simd
-          - running_mode: "fast-jit"
-            test_option: $MULTI_MODULES_TEST_OPTIONS
-          - running_mode: "fast-jit"
-            test_option: $SIMD_TEST_OPTIONS
-          # multi-tier-jit doesn't support multi module, simd
-          - running_mode: "multi-tier-jit"
-            test_option: $MULTI_MODULES_TEST_OPTIONS
-          - running_mode: "multi-tier-jit"
-            test_option: $SIMD_TEST_OPTIONS
+            sanitizer: ubsan
     steps:
       - name: checkout
         uses: actions/checkout@v4
diff --git a/tests/wamr-test-suites/test_wamr.sh b/tests/wamr-test-suites/test_wamr.sh
index 57cef635f3..9c9aa9b56c 100755
--- a/tests/wamr-test-suites/test_wamr.sh
+++ b/tests/wamr-test-suites/test_wamr.sh
@@ -478,9 +478,9 @@ function spec_test()
         fi
 
         # As of version 1.0.36, wabt is still unable to correctly handle the GC proposal.
-        # 
+        #
         # $ $ /opt/wabt-1.0.36/bin/wast2json --enable-all ../spec/test/core/br_if.wast
-        # 
+        #
         # ../spec/test/core/br_if.wast:670:26: error: unexpected token "null", expected a numeric index or a name (e.g. 12 or $foo).
         #     (func $f (param (ref null $t)) (result funcref) (local.get 0))
         #
@@ -877,11 +877,23 @@ function do_execute_in_running_mode()
 {
     local RUNNING_MODE="$1"
 
-    if [[ ${ENABLE_MULTI_MEMORY} -eq 1 ]]; then
+    # filter out uncompatible running mode based on targeting proposal features
+    # keep alpha order
+
+    if [[ ${ENABLE_EH} -eq 1 ]]; then
+        if [[ "${RUNNING_MODE}" != "classic-interp" ]]; then
+            echo "support exception handling in classic-interp"
+            return 0;
+        fi
+    fi
+
+    if [[ ${ENABLE_GC} -eq 1 ]]; then
         if [[ "${RUNNING_MODE}" != "classic-interp" \
+                && "${RUNNING_MODE}" != "fast-interp" \
+                && "${RUNNING_MODE}" != "jit" \
                 && "${RUNNING_MODE}" != "aot" ]]; then
-            echo "support multi-memory in classic-interp mode and aot mode"
-            return 0
+            echo "support gc in both interp modes, llvm-jit mode and aot mode"
+            return 0;
         fi
     fi
 
@@ -893,6 +905,13 @@ function do_execute_in_running_mode()
         fi
     fi
 
+    if [[ ${ENABLE_MULTI_MEMORY} -eq 1 ]]; then
+        if [[ "${RUNNING_MODE}" != "classic-interp" ]]; then
+            echo "support multi-memory in classic-interp mode mode"
+            return 0
+        fi
+    fi
+
     if [[ ${ENABLE_MULTI_MODULE} -eq 1 ]]; then
         if [[ "${RUNNING_MODE}" != "classic-interp" \
                 && "${RUNNING_MODE}" != "fast-interp" \
@@ -902,6 +921,14 @@ function do_execute_in_running_mode()
         fi
     fi
 
+    if [[ ${ENABLE_SIMD} -eq 1 ]]; then
+        if [[ "${RUNNING_MODE}" != "jit" && "${RUNNING_MODE}" != "aot" && "${RUNNING_MODE}" != "fast-interp" ]]; then
+            echo "support simd in llvm-jit, aot and fast-interp mode"
+            return 0;
+        fi
+    fi
+
+    # filter out uncompatible running mode based on SGX support
     if [[ ${SGX_OPT} == "--sgx" ]]; then
         if [[ "${RUNNING_MODE}" != "classic-interp" \
                 && "${RUNNING_MODE}" != "fast-interp" \
@@ -912,33 +939,25 @@ function do_execute_in_running_mode()
         fi
     fi
 
-    if [[ ${ENABLE_SIMD} -eq 1 ]]; then
-        if [[ "${RUNNING_MODE}" != "jit" && "${RUNNING_MODE}" != "aot" && "${RUNNING_MODE}" != "fast-interp" ]]; then
-            echo "support simd in llvm-jit, aot and fast-interp mode"
+    # filter out uncompatible running mode based on architecture
+    if [[ ${TARGET} == "X86_32" ]]; then
+        if [[ "${RUNNING_MODE}" == "jit" || "${RUNNING_MODE}" == "fast-jit" || "${RUNNING_MODE}" == "multi-tier-jit" ]]; then
+            echo "both llvm-jit, fast-jit and multi-tier-jit mode do not support X86_32 target"
             return 0;
         fi
-    fi
 
-    if [[ ${TARGET} == "X86_32" ]]; then
-        if [[ "${RUNNING_MODE}" == "jit" || "${RUNNING_MODE}" == "fast-jit" ]]; then
-            echo "both llvm-jit mode and fast-jit mode do not support X86_32 target"
+        if [[ ${ENABLE_MEMORY64} -eq 1 ]]; then
+            echo "memory64 does not support X86_32 target"
             return 0;
         fi
-    fi
 
-    if [[ ${ENABLE_GC} -eq 1 ]]; then
-        if [[ "${RUNNING_MODE}" != "classic-interp" \
-                && "${RUNNING_MODE}" != "fast-interp" \
-                && "${RUNNING_MODE}" != "jit" \
-                && "${RUNNING_MODE}" != "aot" ]]; then
-            echo "support gc in both interp modes, llvm-jit mode and aot mode"
+        if [[ ${ENABLE_MULTI_MEMORY} -eq 1 ]]; then
+            echo "multi-memory does not support X86_32 target"
             return 0;
         fi
-    fi
 
-    if [[ ${ENABLE_EH} -eq 1 ]]; then
-        if [[ "${RUNNING_MODE}" != "classic-interp" ]]; then
-            echo "support exception handling in classic-interp"
+        if [[ ${ENABLE_SIMD} -eq 1 ]]; then
+            echo "simd does not support X86_32 target"
             return 0;
         fi
     fi