db_Universe
Homeodomain (Hox) Transcription Factors Members of this transcription factor family are characterized by the presence of a homeodomain, which is a 60 amino acid helix-turn-helix DNA-binding domain. The DNA sequence that encodes the homeodomain is called the "homeobox" and homeobox-containing genes are known as "hox genes." The homeodomain is very highly conserved and consists of three helical regions folded into a tight globular structure that binds a 5'-TAAT-3' core motif. The recognition helix within the homeodomain binds the DNA major groove while the amino-terminal tail contacts the DNA minor groove. Interestingly, the homeodomain is also important for nucleocytoplasmic trafficking of hox transcription factors. Members of the hox transcription factor family can function as monomers or homodimers to directly drive transcription of target genes. The major function of hox transcription factors is to pattern the embryonic anterior-posterior body axis. More specifically, hox gene expression is crucial for normal temporospatial limb and organ development.
ADNP
ARX
ATBF1/ZFHX3
CDX2
CDX4
CRX
DLX5
DUX4
DUX4/DUX4c
DUX4c
EMX2
Goosecoid
HHEX
HNF-6/ONECUT1
HOXA1
HOXB1
HOXB7
HOXB13
HOXD10
Islet-1
Islet-2
LHX5
LIM1
MSX1
MSX2
Nanog
NKX2.2
NKX2.5
NKX3.1
NKX6.1
Oct-3/4
Oct-4A
Oct-4B
ONECUT2/OC-2
Otx2
PDX-1/IPF1
PHOX2B
PITX2
POU3F2
Prox1
SATB1
TCF-2/HNF-1 beta
TCF-3/E2A
TGIF1
TTF-1/NKX2-1
VSTM2L
ZEB1
1 Homeobox proteins. A homeobox is about 180 base pairs long and encodes a 60-aa domain (the homeodomain) which when expressed (i.e. as protein) can bind DNA. Homeobox-containing genes encode transcription factors (homeobox proteins) that typically switch on/off cascades of other genes.
on Physic Chemie db_ord_genial enad ძialect Русский
1 Гомеобоксные белки. Гомеобокс состоит примерно из 180 пар оснований и кодирует домен из 60 аминокислот (гомеодомен), который при экспрессии (т. е. в виде белка) может связывать ДНК . Гены, содержащие гомеобокс, кодируют факторы транскрипции (гомеобокс-белки), которые обычно включают/выключают каскады других генов.
https://en.wikipedia.org/wiki/Hox_gene
