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Using JNI's NewDirectByteBuffer function, one can wrap an existing memory address and length into an off-heap ByteBuffer. Now that ImgLib2 supports ByteBuffer-backed data, we could make use of this to have zero-copy access to NumPy arrays from Java without the Unsafe hacks currently used. This would hopefully make the imglib2-unsafe library obsolete.
We need to determine the best way to call that JNI function. It is used in the JPype project in a few places; perhaps there is an existing JPype call we can use, without needing to resort to our own Cython code or use of JNA... Edit: It should be as simple as calling jpype.nio.convertToDirectBuffer(narr) on the numpy array and feeding the resultant DirectByteBuffer to ImgLib2. After verifying this indeed does not copy the data, of course.