diff --git a/src/instana/instrumentation/fastapi.py b/src/instana/instrumentation/fastapi.py
index b2e9b018..68b19f6a 100644
--- a/src/instana/instrumentation/fastapi.py
+++ b/src/instana/instrumentation/fastapi.py
@@ -71,6 +71,10 @@ def init_with_instana(
             kwargs["middleware"] = [Middleware(InstanaASGIMiddleware)]
         elif isinstance(middleware, list):
             middleware.append(Middleware(InstanaASGIMiddleware))
+        elif isinstance(middleware, tuple):
+            kwargs["middleware"] =  (*middleware, Middleware(InstanaASGIMiddleware))
+        else:
+            logger.warning("Unsupported FastAPI middleware sequence type.")
 
         exception_handlers = kwargs.get("exception_handlers")
         if exception_handlers is None: