diff --git a/driver/cl_options.cpp b/driver/cl_options.cpp
index d230bc0f12..58d38536a0 100644
--- a/driver/cl_options.cpp
+++ b/driver/cl_options.cpp
@@ -223,6 +223,32 @@ cl::opt<bool> emitDwarfDebugInfo(
     "gdwarf", cl::ZeroOrMore,
     cl::desc("Emit DWARF debuginfo (instead of CodeView) for MSVC targets"));
 
+// Prefix map for filenames in DWARF debuginfo
+std::map<std::string, std::string> debugPrefixMap;
+
+struct DwarfPrefixParser : public cl::parser<std::string> {
+  explicit DwarfPrefixParser(cl::Option &O) : cl::parser<std::string>(O) {}
+
+  bool parse(cl::Option &O, llvm::StringRef /*ArgName*/, llvm::StringRef Arg,
+             std::string & /*Val*/) {
+    auto [from, to] = Arg.split('=');
+    if (from.empty() || to.empty()) {
+      return O.error("invalid debug prefix map: " + Arg);
+    }
+    auto fromStr = std::string(from);
+    if (debugPrefixMap.find(fromStr) != debugPrefixMap.end()) {
+      return O.error("debug prefix map already contains: " + fromStr);
+    }
+    debugPrefixMap[fromStr] = std::string(to);
+    return false;
+  }
+};
+
+static cl::opt<std::string, false, DwarfPrefixParser> fdebugPrefixMap(
+    "fdebug-prefix-map", cl::ZeroOrMore,
+    cl::desc("Prefix map for filenames in DWARF debuginfo"),
+    cl::value_desc("<old>=<new>"));
+
 cl::opt<bool> noAsm("noasm", cl::desc("Disallow use of inline assembler"),
                     cl::ZeroOrMore);
 
diff --git a/driver/cl_options.h b/driver/cl_options.h
index 01596ccc8e..8d1d6208ff 100644
--- a/driver/cl_options.h
+++ b/driver/cl_options.h
@@ -20,6 +20,7 @@
 #include "llvm/ADT/SmallVector.h"
 #include "llvm/Support/CodeGen.h"
 #include "llvm/Support/CommandLine.h"
+#include <map>
 #include <deque>
 #include <vector>
 
@@ -149,4 +150,6 @@ extern cl::opt<bool> dynamicCompileTlsWorkaround;
 #else
 constexpr bool enableDynamicCompile = false;
 #endif
+// Prefix map for filenames in DWARF debuginfo
+extern std::map<std::string, std::string> debugPrefixMap;
 }
diff --git a/gen/dibuilder.cpp b/gen/dibuilder.cpp
index 3b5c7470f2..1872e914b5 100644
--- a/gen/dibuilder.cpp
+++ b/gen/dibuilder.cpp
@@ -218,6 +218,15 @@ void DIBuilder::SetValue(Loc loc, llvm::Value *value,
                                    IR->scopebb());
 }
 
+std::string DIBuilder::remapDIPath(llvm::StringRef path) {
+  for (const auto &[from, to] : opts::debugPrefixMap) {
+    if (path.starts_with(from)) {
+      return to + path.substr(from.size()).str();
+    }
+  }
+  return std::string(path);
+}
+
 DIFile DIBuilder::CreateFile(const char *filename) {
   if (!filename)
     filename = IR->dmodule->srcfile.toChars();
@@ -231,14 +240,14 @@ DIFile DIBuilder::CreateFile(const char *filename) {
   //   ...)
 
   if (llvm::sys::path::is_absolute(filename)) {
-    return DBuilder.createFile(llvm::sys::path::relative_path(filename),
-                               llvm::sys::path::root_path(filename));
+    return DBuilder.createFile(remapDIPath(llvm::sys::path::relative_path(filename)),
+                               remapDIPath(llvm::sys::path::root_path(filename)));
   }
 
   llvm::SmallString<128> cwd;
   llvm::sys::fs::current_path(cwd);
 
-  return DBuilder.createFile(filename, cwd);
+  return DBuilder.createFile(remapDIPath(filename), remapDIPath(cwd));
 }
 
 DIFile DIBuilder::CreateFile(Loc loc) {
diff --git a/gen/dibuilder.h b/gen/dibuilder.h
index 01ee7d0477..2d506e38db 100644
--- a/gen/dibuilder.h
+++ b/gen/dibuilder.h
@@ -163,6 +163,7 @@ class DIBuilder {
                  llvm::SmallVector<llvm::Metadata *, 16> &elems);
   void AddStaticMembers(AggregateDeclaration *sd, ldc::DIFile file,
                  llvm::SmallVector<llvm::Metadata *, 16> &elems);
+  std::string remapDIPath(llvm::StringRef path);
   DIFile CreateFile(const char *filename = nullptr);
   DIFile CreateFile(Loc loc);
   DIFile CreateFile(Dsymbol *decl);