diff --git a/docs/release_notes/next/dev-2330-PyInstaller-Qt-Bindings b/docs/release_notes/next/dev-2330-PyInstaller-Qt-Bindings
new file mode 100644
index 00000000000..a59a0ee39a9
--- /dev/null
+++ b/docs/release_notes/next/dev-2330-PyInstaller-Qt-Bindings
@@ -0,0 +1 @@
+#2330: The PySide6 module is now excluded when building via PyInstaller due to hook clashes
\ No newline at end of file
diff --git a/packaging/PackageWithPyInstaller.py b/packaging/PackageWithPyInstaller.py
index daf1b50cf13..80ba7b24cdd 100644
--- a/packaging/PackageWithPyInstaller.py
+++ b/packaging/PackageWithPyInstaller.py
@@ -89,7 +89,7 @@ def add_optional_arguments(run_options):
 
 
 def add_exclude_modules(run_options):
-    excludes = ['matplotlib', 'dask', 'pandas']
+    excludes = ['matplotlib', 'dask', 'pandas', 'PySide6']
     for exclude in excludes:
         run_options.extend(['--exclude-module', exclude])