diff --git a/StackExchangeRedis/NHibernate.Caches.StackExchangeRedis/DefaultCacheRegionStrategyFactory.cs b/StackExchangeRedis/NHibernate.Caches.StackExchangeRedis/DefaultCacheRegionStrategyFactory.cs
index b1a2866..0433f57 100644
--- a/StackExchangeRedis/NHibernate.Caches.StackExchangeRedis/DefaultCacheRegionStrategyFactory.cs
+++ b/StackExchangeRedis/NHibernate.Caches.StackExchangeRedis/DefaultCacheRegionStrategyFactory.cs
@@ -19,6 +19,18 @@ public virtual AbstractRegionStrategy Create(IConnectionMultiplexer connectionMu
 			{
 				return new FastRegionStrategy(connectionMultiplexer, configuration, properties);
 			}
+			
+			if (configuration.RegionStrategy == typeof(FastTwoLayerCacheRegionStrategy) ||
+				configuration.RegionStrategy == typeof(TwoLayerCacheRegionStrategy) ||
+				configuration.RegionStrategy == typeof(DistributedLocalCacheRegionStrategy))
+			{
+				throw new CacheException(
+				$"{configuration.RegionStrategy} is not supported by {GetType()}, register " +
+				$"a custom {typeof(ICacheRegionStrategyFactory)} or use a supported one. " +
+				$"{configuration.RegionStrategy} requires an application provided implementation " +
+				$"of {nameof(RegionMemoryCacheBase)} and cannot be directly supported by the " +
+				$"{nameof(DefaultCacheRegionStrategyFactory)}.");
+			}
 
 			throw new CacheException(
 				$"{configuration.RegionStrategy} is not supported by {GetType()}, register " +