diff --git a/Include/internal/pycore_uop_metadata.h b/Include/internal/pycore_uop_metadata.h
index 5ebe124983b862..56fe74c5c8e94e 100644
--- a/Include/internal/pycore_uop_metadata.h
+++ b/Include/internal/pycore_uop_metadata.h
@@ -319,7 +319,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_FATAL_ERROR] = 0,
     [_DEOPT] = 0,
     [_ERROR_POP_N] = HAS_ARG_FLAG,
-    [_TIER2_RESUME_CHECK] = HAS_DEOPT_FLAG,
+    [_TIER2_RESUME_CHECK] = HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
 };
 
 const uint8_t _PyUop_Replication[MAX_UOP_ID+1] = {
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2025-05-26-15-17-29.gh-issue-134728.YUJYfF.rst b/Misc/NEWS.d/next/Core_and_Builtins/2025-05-26-15-17-29.gh-issue-134728.YUJYfF.rst
new file mode 100644
index 00000000000000..bc262f8e7e2f46
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2025-05-26-15-17-29.gh-issue-134728.YUJYfF.rst
@@ -0,0 +1 @@
+Handle ``_TIER2_RESUME_CHECK`` in the JIT.
diff --git a/Python/bytecodes.c b/Python/bytecodes.c
index be22c7446f5402..78971e3738e67f 100644
--- a/Python/bytecodes.c
+++ b/Python/bytecodes.c
@@ -5392,15 +5392,16 @@ dummy_func(
             GOTO_TIER_ONE(NULL);
         }
 
-        /* Progress is guaranteed if we DEOPT on the eval breaker, because
-         * ENTER_EXECUTOR will not re-enter tier 2 with the eval breaker set. */
         tier2 op(_TIER2_RESUME_CHECK, (--)) {
 #if defined(__EMSCRIPTEN__)
             DEOPT_IF(_Py_emscripten_signal_clock == 0);
             _Py_emscripten_signal_clock -= Py_EMSCRIPTEN_SIGNAL_HANDLING;
 #endif
             uintptr_t eval_breaker = _Py_atomic_load_uintptr_relaxed(&tstate->eval_breaker);
-            DEOPT_IF(eval_breaker & _PY_EVAL_EVENTS_MASK);
+            if (eval_breaker & _PY_EVAL_EVENTS_MASK) {
+                int err = _Py_HandlePending(tstate);
+                ERROR_IF(err != 0);
+            }
             assert(tstate->tracing || eval_breaker == FT_ATOMIC_LOAD_UINTPTR_ACQUIRE(_PyFrame_GetCode(frame)->_co_instrumentation_version));
         }
 
diff --git a/Python/executor_cases.c.h b/Python/executor_cases.c.h
index 40090e692e4a72..948cb95b6c176c 100644
--- a/Python/executor_cases.c.h
+++ b/Python/executor_cases.c.h
@@ -7303,8 +7303,12 @@
             #endif
             uintptr_t eval_breaker = _Py_atomic_load_uintptr_relaxed(&tstate->eval_breaker);
             if (eval_breaker & _PY_EVAL_EVENTS_MASK) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                int err = _Py_HandlePending(tstate);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+                if (err != 0) {
+                    JUMP_TO_ERROR();
+                }
             }
             assert(tstate->tracing || eval_breaker == FT_ATOMIC_LOAD_UINTPTR_ACQUIRE(_PyFrame_GetCode(frame)->_co_instrumentation_version));
             break;