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We need zarr support in R to be able to write expression matrices, and potentially to write hdf5 or other objects directly to zarr representations (like AnnData.write_zarr) See https://github.com/gdkrmr/zarr-R
There is also a lot of interest in other places zarr-developers/community#18 https://spacetx-starfish.readthedocs.io/en/stable/help_and_reference/working_with_starfish_outputs/IntensityTable/#serialization
mdsumner
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